ChloroquineV1, France, Analysis, bibRecord, 000311

Simalikalactone D is responsible for the antimalarial properties of an Amazonian traditional remedy made with Quassia amara L. (Simaroubaceae)

Identifieur interne : 000311 ( France/Analysis ); précédent : 000310; suivant : 000312

Simalikalactone D is responsible for the antimalarial properties of an Amazonian traditional remedy made with Quassia amara L. (Simaroubaceae)

Auteurs : Stephane Bertani [France] ; Emeline Houel ; Didier Stien ; Lionel Chevolot [France] ; Valérie Jullian [France] ; Giovanni Garavito [Colombie] ; Genevieve Bourdy [France] ; Eric Deharo [France]

Source :

Journal of Ethnopharmacology [ 0378-8741 ] ; 2007-04.

RBID : Hal:hal-00384337

Abstract

French Guiana (North-East Amazonia) records high malaria incidence rates. The traditional antimalarial remedy most widespread there is a simple tea made out from Quassia amara L. leaves (Simaroubaceae). This herbal tea displays an excellent antimalarial activity both in vitro and in vivo. A known quassinoid, simalikalactone D (SkD), was identified as the active compound, with an IC50 value of 10nM against FcB1 Plasmodium falciparum chloroquine resistant strain in vitro. Lastly, it inhibits 50% of Plasmodium yoelii yoelii rodent malaria parasite at 3.7 mg/kg/day in vivo by oral route. These findings confirm the traditional use of this herbal tea.

Url:

https://hal.archives-ouvertes.fr/hal-00384337

DOI: 10.1016/j.jep.2006.04.017

Affiliations:

Colombie, France

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000216
to stream Hal, to step Curation: 000216
to stream Hal, to step Checkpoint: 000224
to stream Main, to step Merge: 001A60
to stream Main, to step Curation: 001A50
to stream Main, to step Exploration: 001A50
to stream France, to step Extraction: 000311

Links to Exploration step

Hal:hal-00384337

Le document en format XML

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          <desc>            <address>              <addrLine>745 BP 709 - F-97387 Kourou Cedex France</addrLine>
              <country key="GF"></country>
            </address>
            <ref type="url">http://www.ecofog.gf/</ref>
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          <orgName>Centre de Coopération Internationale en Recherche Agronomique pour le Développement</orgName>
          <orgName type="acronym">Cirad</orgName>
          <date type="start">1984-06-01</date>
          <desc>            <address>              <addrLine>Siège 42, rue Scheffer 75116 Paris</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cirad.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR0745" active="#struct-92114" type="direct"><org type="institution" xml:id="struct-92114" status="OLD">          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-93016" type="direct"><org type="institution" xml:id="struct-93016" status="OLD">          <idno type="IdRef">026603136</idno>
          <orgName>Université des Antilles et de la Guyane</orgName>
          <orgName type="acronym">UAG</orgName>
          <date type="start">1982-07-02</date>
          <date type="end">2015-06-24</date>
          <desc>            <address>              <addrLine>Fouillole - BP 250 - 97157 Pointe-à-Pitre</addrLine>
              <country key="GP"></country>
            </address>
            <ref type="url">http://www.univ-ag.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-148117" type="direct"><org type="institution" xml:id="struct-148117" status="VALID">          <orgName>AgroParisTech</orgName>
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              <country key="FR"></country>
            </address>
            <ref type="url">http://www.agroparistech.fr/</ref>
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          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
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            <ref type="url">http://www.cnrs.fr/</ref>
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</hal:affiliation>
<wicri:noCountry>GF</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Chevolot, Lionel" sort="Chevolot, Lionel" uniqKey="Chevolot L" first="Lionel" last="Chevolot">Lionel Chevolot</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-1836" status="VALID">          <orgName>UPS CNRS Guyane</orgName>
          <orgName type="acronym">UCG</orgName>
          <desc>            <address>              <addrLine>Résidence Le Relais 16 Avenue André Aron 97300 CAYENNE</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="UPS2561" active="#struct-441569" type="direct"></relation>
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          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
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            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
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</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Jullian, Valerie" sort="Jullian, Valerie" uniqKey="Jullian V" first="Valérie" last="Jullian">Valérie Jullian</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-12806" status="VALID">          <orgName>Pharmacochimie des substances naturelles et pharmacophores redox</orgName>
          <desc>            <address>              <addrLine>Université Paul SabatierFaculté de pharmacie35 Chemin des Maraîchers31062 Toulouse Cedex France </addrLine>
              <country key="FR"></country>
            </address>
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          <idno type="ISNI">0000000121617331</idno>
          <orgName>Université Toulouse III - Paul Sabatier</orgName>
          <orgName type="acronym">UT3</orgName>
          <desc>            <address>              <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine>
              <country key="FR"></country>
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              <country key="FR"></country>
            </address>
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</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Garavito, Giovanni" sort="Garavito, Giovanni" uniqKey="Garavito G" first="Giovanni" last="Garavito">Giovanni Garavito</name>
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        </org>
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</hal:affiliation>
<country>Colombie</country>
</affiliation>
</author>
<author><name sortKey="Bourdy, Genevieve" sort="Bourdy, Genevieve" uniqKey="Bourdy G" first="Genevieve" last="Bourdy">Genevieve Bourdy</name>
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          <desc>            <address>              <addrLine>UNIVERSITE PAUL SABATIER TOULOUSE 3 31062 TOULOUSE CEDEX 09</addrLine>
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          </desc>
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          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Deharo, Eric" sort="Deharo, Eric" uniqKey="Deharo E" first="Eric" last="Deharo">Eric Deharo</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-12806" status="VALID">          <orgName>Pharmacochimie des substances naturelles et pharmacophores redox</orgName>
          <desc>            <address>              <addrLine>Université Paul SabatierFaculté de pharmacie35 Chemin des Maraîchers31062 Toulouse Cedex France </addrLine>
              <country key="FR"></country>
            </address>
          </desc>
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          <idno type="ISNI">0000000121617331</idno>
          <orgName>Université Toulouse III - Paul Sabatier</orgName>
          <orgName type="acronym">UT3</orgName>
          <desc>            <address>              <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-tlse3.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-443875" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-443875" type="indirect"><org type="regroupinstitution" xml:id="struct-443875" status="VALID">          <orgName>Université Fédérale Toulouse Midi-Pyrénées</orgName>
          <desc>            <address>              <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/j.jep.2006.04.017</idno>
<series><title level="j">Journal of Ethnopharmacology</title>
<idno type="ISSN">0378-8741</idno>
<imprint><date type="datePub">2007-04</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="it"><term>Antimalarial</term>
<term>Quassia amara</term>
<term>Quassinoids</term>
<term>Simalikalactone D</term>
<term>Traditional medicine</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>French Guiana (North-East Amazonia) records high malaria incidence rates. The traditional antimalarial remedy most widespread there is a simple tea made out from Quassia amara L. leaves (Simaroubaceae). This herbal tea displays an excellent antimalarial activity both in vitro and in vivo. A known quassinoid, simalikalactone D (SkD), was identified as the active compound, with an IC50 value of 10nM against FcB1 Plasmodium falciparum chloroquine resistant strain in vitro. Lastly, it inhibits 50% of Plasmodium yoelii yoelii rodent malaria parasite at 3.7 mg/kg/day in vivo by oral route. These findings confirm the traditional use of this herbal tea.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>Colombie</li>
<li>France</li>
</country>
</list>
<tree><noCountry><name sortKey="Houel, Emeline" sort="Houel, Emeline" uniqKey="Houel E" first="Emeline" last="Houel">Emeline Houel</name>
<name sortKey="Stien, Didier" sort="Stien, Didier" uniqKey="Stien D" first="Didier" last="Stien">Didier Stien</name>
</noCountry>
<country name="France"><noRegion><name sortKey="Bertani, Stephane" sort="Bertani, Stephane" uniqKey="Bertani S" first="Stephane" last="Bertani">Stephane Bertani</name>
</noRegion>
<name sortKey="Bourdy, Genevieve" sort="Bourdy, Genevieve" uniqKey="Bourdy G" first="Genevieve" last="Bourdy">Genevieve Bourdy</name>
<name sortKey="Chevolot, Lionel" sort="Chevolot, Lionel" uniqKey="Chevolot L" first="Lionel" last="Chevolot">Lionel Chevolot</name>
<name sortKey="Deharo, Eric" sort="Deharo, Eric" uniqKey="Deharo E" first="Eric" last="Deharo">Eric Deharo</name>
<name sortKey="Jullian, Valerie" sort="Jullian, Valerie" uniqKey="Jullian V" first="Valérie" last="Jullian">Valérie Jullian</name>
</country>
<country name="Colombie"><noRegion><name sortKey="Garavito, Giovanni" sort="Garavito, Giovanni" uniqKey="Garavito G" first="Giovanni" last="Garavito">Giovanni Garavito</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Simalikalactone D is responsible for the antimalarial properties of an Amazonian traditional remedy made with Quassia amara L. (Simaroubaceae)

Simalikalactone D is responsible for the antimalarial properties of an Amazonian traditional remedy made with Quassia amara L. (Simaroubaceae)

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